Article
Molecular Classification of Grade 3 Endometrioid Endometrial Cancers Identifies Distinct Prognostic Subgroups.
The American journal of surgical pathology - 1 May 2018
Bosse Tjalling, Nout Remi A, McAlpine Jessica N, McConechy Melissa K, Britton Heidi, Hussein Yaser R, Gonzalez Carlene, Ganesan Raji, Steele Jane C, Harrison Beth T, Oliva Esther, Vidal August, Matias-Guiu Xavier, Abu-Rustum Nadeem R, Levine Douglas A, Gilks C Blake, Soslow Robert A
Abstract excerpt
Our aim was to investigate whether molecular classification can be used to refine prognosis in grade 3 endometrial endometrioid carcinomas (EECs). Grade 3 EECs were classified into 4 subgroups: p53 abnormal, based on mutant-like immunostaining (p53abn); MMR deficient, based on loss of mismatch repair protein expression (MMRd); presence of POLE exonuclease domain hotspot mutation (POLE); no specific molecular...
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