Article
Prognostic significance of POLE proofreading mutations in endometrial cancer.
Journal of the National Cancer Institute - 1 Jan 2015
Church David N, Stelloo Ellen, Nout Remi A, Valtcheva Nadejda, Depreeuw Jeroen, ter Haar Natalja, Noske Aurelia, Amant Frederic, Tomlinson Ian P M, Wild Peter J, Lambrechts Diether, Jürgenliemk-Schulz Ina M, Jobsen Jan J, Smit Vincent T H B M, Creutzberg Carien L, Bosse Tjalling
Abstract excerpt
BACKGROUND: Current risk stratification in endometrial cancer (EC) results in frequent over- and underuse of adjuvant therapy, and may be improved by novel biomarkers. We examined whether POLE proofreading mutations, recently reported in about 7% of ECs, predict prognosis. METHODS: We performed targeted POLE sequencing in ECs from the PORTEC-1 and -2 trials (n = 788), and analyzed clinical outcome according to...
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