Article
TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs.
Nature neuroscience - 1 Sept 2013
Studniarczyk Dorota, Coombs Ian, Cull-Candy Stuart G, Farrant Mark
Abstract excerpt
Regulation of calcium-permeable AMPA receptors (CP-AMPARs) is crucial in normal synaptic function and neurological disease states. Although transmembrane AMPAR regulatory proteins (TARPs) such as stargazin (γ-2) modulate the properties of calcium-impermeable AMPARs (CI-AMPARs) and promote their synaptic targeting, the TARP-specific rules governing CP-AMPAR synaptic trafficking remain unclear. We used RNA...
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