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Article

A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Mar 2016

Alsaloum Matthew, Kazi Rashek, Gan Quan, Amin Johansen, Wollmuth Lonnie P

Abstract excerpt

AMPA and NMDA receptors are glutamate-gated ion channels that mediate fast excitatory synaptic transmission throughout the nervous system. In the continual presence of glutamate, AMPA and NMDA receptors containing the GluN2A or GluN2B subunit enter into a nonconducting, desensitized state that can impact synaptic responses and glutamate-mediated excitotoxicity. The process of desensitization is dramatically...

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Identifiers

PMID: 26937003
DOI: 10.1523/JNEUROSCI.2667-15.2016
PMCID: PMC4879209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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