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Article

Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation.

Human molecular genetics - 15 May 2016

Wang Zong-Heng, Clark Cheryl, Geisbrecht Erika R

Abstract excerpt

PINK1/Parkin-mediated mitochondrial quality control (MQC) requires valosin-containing protein (VCP)-dependent Mitofusin/Marf degradation to prevent damaged organelles from fusing with the healthy mitochondrial pool, facilitating mitochondrial clearance by autophagy. Drosophila clueless (clu) was found to interact genetically with PINK1 and parkin to regulate mitochondrial clustering in germ cells. However,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26931463
DOI: 10.1093/hmg/ddw067
PMCID: PMC5062585

Genes

VCP
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation.PMID 26931463Read ↗

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