Article
Clueless, a protein required for mitochondrial function, interacts with the PINK1-Parkin complex in Drosophila.
Disease models & mechanisms - 1 Jun 2015
Sen Aditya, Kalvakuri Sreehari, Bodmer Rolf, Cox Rachel T
Abstract excerpt
Loss of mitochondrial function often leads to neurodegeneration and is thought to be one of the underlying causes of neurodegenerative diseases such as Parkinson's disease (PD). However, the precise events linking mitochondrial dysfunction to neuronal death remain elusive. PTEN-induced putative kinase 1 (PINK1) and Parkin (Park), either of which, when mutated, are responsible for early-onset PD, mark individual...
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