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Article

The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway.

PloS one - 7 Apr 2010

Poole Angela C, Thomas Ruth E, Yu Selina, Vincow Evelyn S, Pallanck Leo

Abstract excerpt

Loss-of-function mutations in the PINK1 or parkin genes result in recessive heritable forms of parkinsonism. Genetic studies of Drosophila orthologs of PINK1 and parkin indicate that PINK1, a mitochondrially targeted serine/threonine kinase, acts upstream of Parkin, a cytosolic ubiquitin-protein ligase, to promote mitochondrial fragmentation, although the molecular mechanisms by which the PINK1/Parkin pathway...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20383334
DOI: 10.1371/journal.pone.0010054
PMCID: PMC2850930

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway.PMID 20383334Read ↗

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila.Semantic proximity Read ↗

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.Semantic proximity Read ↗

The PINK1/Parkin pathway regulates mitochondrial morphology.Semantic proximity Read ↗

How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?Semantic proximity Read ↗

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1.Semantic proximity Read ↗

Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.Semantic proximity Read ↗

Atg1-mediated autophagy suppresses tissue degeneration inpink1/parkinmutants by promoting mitochondrial fission inDrosophilaSemantic proximity Read ↗

The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process.Semantic proximity Read ↗

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagySemantic proximity Read ↗

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery.Semantic proximity Read ↗

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin.Semantic proximity Read ↗

E2 ubiquitin conjugase Bendless is essential for PINK1-Park activity to regulate Mitofusin under mitochondrial stressSemantic proximity Read ↗

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