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Article

CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice

18 Oct 2018

Abstract excerpt

A perplexing question in neurodegeneration is why different neurons degenerate. The Purkinje cell degeneration (pcd) mouse displays a dramatic phenotype of degeneration of cerebellar Purkinje cells. Loss of CCP1/Nna1 deglutamylation of tubulin accounts for pcd neurodegeneration, but the mechanism is unknown. In this study, we modulated the dosage of fission and fusion genes in a Drosophila melanogaster...

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PMID: 30337352
DOI: 10.1083/jcb.201709028

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