Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations.

Neuron - 10 Apr 2013

Kim Nam Chul, Tresse Emilie, Kolaitis Regina-Maria, Molliex Amandine, Thomas Ruth E, Alami Nael H, Wang Bo, Joshi Aashish, Smith Rebecca B, Ritson Gillian P, Winborn Brett J, Moore Jennifer, Lee Joo-Yong, Yao Tso-Pang, Pallanck Leo, Kundu Mondira, Taylor J Paul

Abstract excerpt

Mutations in VCP cause multisystem degeneration impacting the nervous system, muscle, and/or bone. Patients may present with ALS, Parkinsonism, frontotemporal dementia, myopathy, Paget's disease, or a combination of these. The disease mechanism is unknown. We developed a Drosophila model of VCP m...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Carbonyl Cyanide m-Chlorophenyl Hydrazone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ganglia, Spinal

Share to Leupeptins

Share to Mitochondrial Membrane Transport Proteins

Share to Neuromuscular Junction

Share to Ubiquitination

Share to Valosin Containing Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 23498974
DOI: 10.1016/j.neuron.2013.02.029
PMCID: PMC3683300

Genes

VCP
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23498974-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations.PMID 23498974Read ↗

Aberrant nuclear pore complex degradation contributes to neurodegeneration in VCP disease.Semantic proximity Read ↗

Different dynamic movements of wild‐type and pathogenic <scp>VCP</scp>s and their cofactors to damaged mitochondria in a <scp>P</scp>arkin‐mediated mitochondrial quality control systemSemantic proximity Read ↗

Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation.Semantic proximity Read ↗

SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.Semantic proximity Read ↗

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate ParkinSemantic proximity Read ↗

PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity.Semantic proximity Read ↗

PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiencySemantic proximity Read ↗

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin.Semantic proximity Read ↗

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.Semantic proximity Read ↗

CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases.Semantic proximity Read ↗

How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?Semantic proximity Read ↗

Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.