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Article

SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.

Nature communications - 21 Jan 2021

Johnson Alyssa E, Orr Brian O, Fetter Richard D, Moughamian Armen J, Primeaux Logan A, Geier Ethan G, Yokoyama Jennifer S, Miller Bruce L, Davis Graeme W

Abstract excerpt

Missense mutations in Valosin-Containing Protein (VCP) are linked to diverse degenerative diseases including IBMPFD, amyotrophic lateral sclerosis (ALS), muscular dystrophy and Parkinson's disease. Here, we characterize a VCP-binding co-factor (SVIP) that specifically recruits VCP to lysosomes. SVIP is essential for lysosomal dynamic stability and autophagosomal-lysosomal fusion. SVIP mutations cause muscle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33479240
DOI: 10.1038/s41467-020-20796-8
PMCID: PMC7820495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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