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Article

Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin.

Circulation research - 17 Jan 2014

Bhandari Poonam, Song Moshi, Chen Yun, Burelle Yan, Dorn Gerald W

Abstract excerpt

RATIONALE: Dysfunctional Parkin-mediated mitophagic culling of senescent or damaged mitochondria is a major pathological process underlying Parkinson disease and a potential genetic mechanism of cardiomyopathy. Despite epidemiological associations between Parkinson disease and heart failure, the role of Parkin and mitophagic quality control in maintaining normal cardiac homeostasis is poorly understood....

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Source

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Identifiers

PMID: 24192653
DOI: 10.1161/CIRCRESAHA.114.302734
PMCID: PMC4392818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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