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Article

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2010

Ziviani Elena, Tao Ran N, Whitworth Alexander J

Abstract excerpt

Loss of the E3 ubiquitin ligase Parkin causes early onset Parkinson's disease, a neurodegenerative disorder of unknown etiology. Parkin has been linked to multiple cellular processes including protein degradation, mitochondrial homeostasis, and autophagy; however, its precise role in pathogenesis is unclear. Recent evidence suggests that Parkin is recruited to damaged mitochondria, possibly affecting...

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Identifiers

PMID: 20194754
DOI: 10.1073/pnas.0913485107
PMCID: PMC2841909

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.PMID 20194754Read ↗

How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?Semantic proximity Read ↗

The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway.Semantic proximity Read ↗

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1.Semantic proximity Read ↗

Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.Semantic proximity Read ↗

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila.Semantic proximity Read ↗

PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesisSemantic proximity Read ↗

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate ParkinSemantic proximity Read ↗

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagySemantic proximity Read ↗

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons.Semantic proximity Read ↗

Atg1-mediated autophagy suppresses tissue degeneration inpink1/parkinmutants by promoting mitochondrial fission inDrosophilaSemantic proximity Read ↗

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin.Semantic proximity Read ↗

Selective localization of Mfn2 near PINK1 enable its preferential ubiquitination by Parkin on mitochondriaSemantic proximity Read ↗

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