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Article

Association of HLA-B15:13 and HLA-B15:02 with phenytoin-induced severe cutaneous adverse reactions in a Malay population.

The pharmacogenomics journal - 1 Mar 2017

Chang C-C, Ng C-C, Too C-L, Choon S-E, Lee C-K, Chung W-H, Hussein S H, Lim K-S, Murad S

Abstract excerpt

Phenytoin (PHT) is a common cause of severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). Although HLA-B*15:02 is associated with PHT-induced SJS/TEN (PHT-SJS/TEN) in Han Chinese and Thais, the genetic basis for susceptibility to PHT-induced SCARs (PHT-SCAR) in other populations...

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PMID: 26927288
DOI: 10.1038/tpj.2016.10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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