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Article

RIMKLA promotes hypertension by activating PKM2 to trigger VSMC phenotype switch.

Military Medical Research - 1 Jan 2026

Xiang Rui, Liu Wen-Jun, Zhang Xin-Rui, Yan Han, Li Xin, Hou Song, Hu Cheng-Qing, Hu Yun-Tao, Ma Ru-Feng, Li Jing, Chi Yu-Jing, Cui Qing-Hua, Chen Zhen-Zhen, Geng Bin, Yang Ji-Chun

Abstract excerpt

Background: Hypertension affects around one billion adults worldwide, with abnormal glucose metabolism and vascular smooth muscle cell (VSMC) phenotype switch playing crucial roles in its pathogenesis. Pyruvate kinase M2 (PKM2) is a key glycolytic enzyme, but its regulation and roles in VSMC phenotype switch and hypertension are unknown. Using the Gene Importance Calculator (GIC) to predict gene essentiality, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42534441
DOI: 10.1016/j.mmr.2026.100056
PMCID: PMC13420487

Genes

RIMKLA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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