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Article

Impaired Autophagy in APOE4 Astrocytes

30 Mar 2016

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent form of dementia in elderly. Genetic studies revealed allelic segregation of the apolipoprotein E (ApoE) gene in sporadic AD and in families with higher risk of AD. The mechanisms underlying the pathological effects of ApoE4 are not yet entirely clear. Several studies indicate that autophagy, which plays an important role in degradation pathways of proteins,...

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PMID: 26923027
DOI: 10.3233/jad-151101

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