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Article

Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice.

Biochimica et biophysica acta - 1 May 2016

Wang Mengyu, Gao Mingming, Liao Jiawei, Qi Yanfei, Du Ximing, Wang Yuhui, Li Ling, Liu George, Yang Hongyuan

Abstract excerpt

Adipose tissue can store over 50% of whole-body cholesterol; however, the physiological role of adipose tissue in cholesterol metabolism and atherogenesis has not been directly assessed. Here, we examined lipoprotein metabolism and atherogenesis in a unique mouse model of severe lipodystrophy: the Seipin(-/-) mice, and also in mice deficient in both low-density lipoprotein receptor (Ldlr) and Seipin: the...

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Source

Identifiers

PMID: 26921684
DOI: 10.1016/j.bbalip.2016.02.018

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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