IDOL deficiency inhibits cholesterol-rich diet-induced atherosclerosis in rabbits

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> The E3 ubiquitin ligase IDOL (Inducible Degrader of the LDL-Receptor) contributes to regulation of cholesterol metabolism through degradation of LDLR, VLDLR and ApoER2. Human genetic studies support the hypothesis that IDOL could serve as a target for the treatment of dyslipidemia. However, species-specific differences in overall lipid metabolism and IDOL regulation require...

Topics

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• Albumins
• Aortic Diseases
• Apolipoprotein E3
• Diet, High-Fat
• Diet, Western
• Liver X Receptors
• Orphan Nuclear Receptors
• Plaque, Atherosclerotic

Identifiers and source

Literature Corpus work

32cf4a9b-9e51-5119-b1aa-134c00ef6741

DOI

10.1101/2022.05.03.490218