Article
SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem.
Endocrinology - 1 Oct 2020
Kahn Jonathan H, Goddi Anna, Sharma Aishwarya, Heiman Joshua, Carmona Alanis, Li Yan, Hoffman Alexandria, Schoenfelt Kelly, Ye Honggang, Bobe Alexandria M, Becker Lev, Hollenberg Anthony N, Cohen Ronald N
Abstract excerpt
The Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) is a nuclear corepressor, regulating the transcriptional activity of many transcription factors critical for metabolic processes. While the importance of the role of SMRT in the adipocyte has been well-established, our comprehensive understanding of its in vivo function in the context of homeostatic maintenance is limited due to contradictory...
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