Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Seipin ablation in mice results in severe generalized lipodystrophy.

Human molecular genetics - 1 Aug 2011

Cui Xin, Wang Yuhui, Tang Yin, Liu Yixiao, Zhao Liping, Deng Jingna, Xu Guoheng, Peng Xingui, Ju Shenghong, Liu George, Yang Hongyuan

Abstract excerpt

Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is an autosomal recessive disorder characterized by an almost complete loss of adipose tissue, insulin resistance and fatty liver. Here, we create the first murine model of BSCL2 by targeted disruption of seipin, the causative gene for BSC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiponectin
Share to Adipose Tissue
Share to Body Weight

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein gamma Subunits

Share to Leptin

Share to Magnetic Resonance Imaging

Share to Mice, Knockout

Share to Real-Time Polymerase Chain Reaction

Source

Identifiers

PMID: 21551454
DOI: 10.1093/hmg/ddr205

Genes

BSCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21551454-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Seipin ablation in mice results in severe generalized lipodystrophy.PMID 21551454Read ↗

Function of seipin: new insights from Bscl2/seipin knockout mouse models.Semantic proximity Read ↗

Seipin Deficiency as a Model of Severe Adipocyte Dysfunction: Lessons from Rodent Models and Teaching for Human Disease.Semantic proximity Read ↗

Towards a mechanistic understanding of lipodystrophy and seipin functions.Semantic proximity Read ↗

Lack of testicular seipin causes teratozoospermia syndrome in menSemantic proximity Read ↗

Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy.Semantic proximity Read ↗

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte DifferentiationSemantic proximity Read ↗

Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation.Semantic proximity Read ↗

The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology.Semantic proximity Read ↗

Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms.Semantic proximity Read ↗

Seipin: from human disease to molecular mechanism.Semantic proximity Read ↗

Neuroanatomical characterisation of the expression of the lipodystrophy and motor-neuropathy gene Bscl2 in adult mouse brain.Semantic proximity Read ↗

Impaired adipogenic capacity in induced pluripotent stem cells from lipodystrophic patients with BSCL2 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.