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Article

Severe Atherosclerosis and Hypercholesterolemia in Mice Lacking Both the Melanocortin Type 4 Receptor and Low Density Lipoprotein Receptor.

PloS one - 1 Jan 2016

Lede Vera, Franke Christin, Meusel Andrej, Teupser Daniel, Ricken Albert, Thiery Joachim, Schiller Jürgen, Huster Daniel, Schöneberg Torsten, Schulz Angela

Abstract excerpt

Dysfunction of the melanocortin system can result in severe obesity accompanied with dyslipidemia and symptoms of the metabolic syndrome but the effect on vascular atherogenesis is not known. To study the impact of obesity and dyslipidemia on the cardiovascular system, we generated mice double-deficient for the melanocortin type 4 receptor (Mc4rmut mice) and the LDL receptor (Ldlr-/- mice). Mc4rmut mice develop...

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Identifiers

PMID: 28030540
DOI: 10.1371/journal.pone.0167888
PMCID: PMC5193345

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