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Article

The 14-3-3 protein PAR-5 regulates the asymmetric localization of the LET-99 spindle positioning protein.

Developmental biology - 15 Apr 2016

Wu Jui-Ching, Espiritu Eugenel B, Rose Lesilee S

Abstract excerpt

PAR proteins play important roles in establishing cytoplasmic polarity as well as regulating spindle positioning during asymmetric division. However, the molecular mechanisms by which the PAR proteins generate asymmetry in different cell types are still being elucidated. Previous studies in Caenorhabditis elegans revealed that PAR-3 and PAR-1 regulate the asymmetric localization of LET-99, which in turn controls...

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Identifiers

PMID: 26921457
DOI: 10.1016/j.ydbio.2016.02.020
PMCID: PMC4829500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The 14-3-3 protein PAR-5 regulates the asymmetric localization of the LET-99 spindle positioning protein.PMID 26921457Read ↗

PAR-3 and PAR-1 inhibit LET-99 localization to generate a cortical band important for spindle positioning in Caenorhabditis elegans embryos.Semantic proximity Read ↗

The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo.Semantic proximity Read ↗

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PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos.Semantic proximity Read ↗

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aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division.Semantic proximity Read ↗

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.Semantic proximity Read ↗

Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3.Semantic proximity Read ↗

LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.Semantic proximity Read ↗

C. elegans Brat homologs regulate PAR protein-dependent polarity and asymmetric cell division.Semantic proximity Read ↗

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