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Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in <i>Caenorhabditis elegans</i>

15 Sept 1998

Abstract excerpt

Asymmetric cell divisions, critically important to specify cell types in the development of multicellular organisms, require polarized distribution of cytoplasmic components and the proper alignment of the mitotic apparatus. In Caenorhabditis elegans, the maternally expressed protein, PAR-3, is localized to one pole of asymmetrically dividing blastomeres and is required for these asymmetric divisions. In this...

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PMID: 9716526
DOI: 10.1242/dev.125.18.3607

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Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in <i>Caenorhabditis elegans</i>PMID 9716526Read ↗

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.Semantic proximity Read ↗

The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo.Semantic proximity Read ↗

PAR-3 is required for epithelial cell polarity in the distal spermatheca of C. elegans.Semantic proximity Read ↗

MAP kinase signaling antagonizes PAR-1 function during polarization of the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos.Semantic proximity Read ↗

The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry.Semantic proximity Read ↗

Par‐3 family proteins in cell polarity & adhesionSemantic proximity Read ↗

Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3.Semantic proximity Read ↗

Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the <i>Drosophila</i> ovarySemantic proximity Read ↗

PAR-3 mediates the initial clustering and apical localization of junction and polarity proteins during C. elegans intestinal epithelial cell polarization.Semantic proximity Read ↗

The PAR proteins: fundamental players in animal cell polarization.Semantic proximity Read ↗

The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.Semantic proximity Read ↗

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