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Article

Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3.

Genetics - 1 Feb 1995

Cheng N N, Kirby C M, Kemphues K J

Abstract excerpt

Polarized asymmetric divisions play important roles in the development of plants and animals. The first two embryonic cleavages of Caenorhabditis elegans provide an opportunity to study the mechanisms controlling polarized asymmetric divisions. The first cleavage is unequal, producing daughters with different sizes and fates. The daughter blastomeres divide with different orientations at the second cleavage; the...

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Identifiers

PMID: 7713417
DOI: 10.1093/genetics/139.2.549
PMCID: PMC1206366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3.PMID 7713417Read ↗

The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo.Semantic proximity Read ↗

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos.Semantic proximity Read ↗

Mutations in ooc-5 and ooc-3 disrupt oocyte formation and the reestablishment of asymmetric PAR protein localization in two-cell Caenorhabditis elegans embryos.Semantic proximity Read ↗

The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo.Semantic proximity Read ↗

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.Semantic proximity Read ↗

The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote.Semantic proximity Read ↗

C. elegans Brat homologs regulate PAR protein-dependent polarity and asymmetric cell division.Semantic proximity Read ↗

Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

The PAR proteins: fundamental players in animal cell polarization.Semantic proximity Read ↗

Pod-2, along with pod-1, defines a new class of genes required for polarity in the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

MAP kinase signaling antagonizes PAR-1 function during polarization of the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

SPD-3 is required for spindle alignment in Caenorhabditis elegans embryos and localizes to mitochondria.Semantic proximity Read ↗

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