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The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo.

Developmental biology - 1 Jan 2002

Morton Diane G, Shakes Diane C, Nugent Staci, Dichoso Daryl, Wang Wenfu, Golden Andy, Kemphues Kenneth J

Abstract excerpt

The establishment of anterior-posterior polarity in the Caenorhabditis elegans embryo requires the activity of the maternally expressed par genes. We report the identification and analysis of a new par gene, par-5. We show that par-5 is required for asynchrony and asymmetry in the first embryonic cell divisions, normal pseudocleavage, normal cleavage spindle orientation at the two-cell stage, and localization of...

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PMID: 11784094
DOI: 10.1006/dbio.2001.0489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo.PMID 11784094Read ↗

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.Semantic proximity Read ↗

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos.Semantic proximity Read ↗

Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

The 14-3-3 protein PAR-5 regulates the asymmetric localization of the LET-99 spindle positioning protein.Semantic proximity Read ↗

Anterior PAR proteins function during cytokinesis and maintain DYN-1 at the cleavage furrow in Caenorhabditis elegans.Semantic proximity Read ↗

aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division.Semantic proximity Read ↗

The PAR proteins: fundamental players in animal cell polarization.Semantic proximity Read ↗

The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry.Semantic proximity Read ↗

RAB-5 controls the cortical organization and dynamics of PAR proteins to maintain C. elegans early embryonic polarity.Semantic proximity Read ↗

Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases.Semantic proximity Read ↗

The maternal par genes and the segregation of cell fate specification activities in early Caenorhabditis elegans embryos.Semantic proximity Read ↗

The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.Semantic proximity Read ↗

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