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Article

Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle.

American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2000

Boota A, Johnson B, Lee K L, Blaskovich M A, Liu S X, Kagan V E, Hamilton A, Pitt B, Sebti S M, Davies P

Abstract excerpt

We recently showed that the farnesyltransferase inhibitor FTI-277 blocks interleukin 1beta (IL-1beta)-induced nitric oxide production in pulmonary vascular smooth muscle cells (SMC), whereas the geranylgeranyltransferase inhibitor GGTI-298 enhances this effect. Here we show that IL-1beta and platelet-derived growth factor (PDGF) stimulate superoxide production by pulmonary vascular SMC and that this effect is...

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Identifiers

PMID: 10666117
DOI: 10.1152/ajplung.2000.278.2.L329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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