Article

Methylglyoxal Potentiates Palmitic Acid-Induced Endothelial Dysfunction and Atherogenesis in HUVECs

2025-07-31

Abstract excerpt

<title>Abstract</title> <p>Endothelial dysfunction is a key pathological mechanism in atherosclerotic cardiovascular disease, and methylglyoxal (MGO) has been identified as a major contributor to endothelial cell damage through its overabundance. In this study, the effects of MGO on atherosclerotic human endothelial cells were investigated. HUVECs were pre-treated with 1 mM PA for 24 h and then co-treated with 60...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 82365be7-3ae7-58d0-ba87-6373ece3513b
DOI: 10.21203/rs.3.rs-7144495/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Methylglyoxal Potentiates Palmitic Acid-Induced Endothelial Dysfunction and Atherogenesis in HUVECsDOI 10.21203/rs.3.rs-7144495/v1Read

Palmitate-Associated ET-1 and PAI-1 Transcriptional Responses Under High-Glucose Conditions in HUVECs: An Exploratory Glucolipotoxic Stress ModelSemantic proximity Read

Transcription Factor MAFG Protects Mice from High-Fat Diet–Induced Atherosclerosis by Inhibiting Endothelial Cell ApoptosisSemantic proximity Read

Discovery of Diagnostic and Therapeutic Targets For Vascular Injury Induced By Methylglyoxal Using ProteomicsSemantic proximity Read

Trimethylamine-N-oxide affects cell type-specific pathways and networks in mouse aorta to promote atherosclerotic plaque vulnerabilitySemantic proximity Read

Methylglyoxal in Cardiometabolic Disorders – Routes Leading to Pathology – Counterbalanced by Treatment StrategiesSemantic proximity Read

Effect of docosahexaenoic acid plus insulin on atherosclerotic human endothelial cellsSemantic proximity Read

Methylglyoxal Induces Endothelial Dysfunction via Stunning-like PhenotypeSemantic proximity Read

Transcriptional profiles reveal deregulation of lipid metabolism and inflammatory pathways in neurons exposed to palmitic acidSemantic proximity Read

Methylglyoxal Drives a Distinct, Nonclassical Macrophage Activation Status.Semantic proximity Read

Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB.Semantic proximity Read

Hepatocyte-derived exosomal microRNAs orchestrate vascular inflammation and endothelial function: insights into molecular mechanisms of trimethylamine-N-Oxide in atherosclerosisSemantic proximity Read

Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation.Semantic proximity Read