Article
Lipotoxicity, glucotoxicity and some strategies to protect vascular smooth muscle cell against proliferative phenotype in metabolic syndrome.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Feb 2023
López-Acosta Ocarol, Ruiz-Ramírez Angélica, Barrios-Maya Miguel-Ángel, Alarcon-Aguilar Javier, Alarcon-Enos Julio, Céspedes Acuña Carlos L, El-Hafidi Mohammed
Abstract excerpt
Metabolic syndrome (MetS) is a risk factor for the development of cardiovascular disease (CVD) and atherosclerosis through a mechanism that involves vascular smooth muscle cell (VSMC) proliferation, lipotoxicity and glucotoxicity. Several molecules found to be increased in MetS, including free fatty acids, fatty acid binding protein 4, leptin, resistin, oxidized lipoprotein particles, and advanced glycation end...
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