Article

Oxidative Stress and Its Role in Vascular Damage and Atherosclerosis

2025-09-22

Abstract excerpt

Oxidative stress (OS), resulting from an imbalance between reactive oxygen species (ROS) generation and antioxidant defenses, plays a pivotal role in vascular diseases such as atherosclerosis and hypertension. ROS derived from NADPH oxidase, mitochondria, and xanthine oxidase promote endothelial dysfunction by inducing lipid and protein oxidation, apoptosis, and pro-inflammatory signaling, thereby enhancing smooth...

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Literature Corpus work: 165d56a7-3229-509d-99de-8bdc52b7769a
DOI: 10.20944/preprints202509.1844.v1

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