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Article

Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells.

The Journal of cell biology - 22 Feb 2010

Fazzio Thomas G, Panning Barbara

Abstract excerpt

In an RNA interference screen interrogating regulators of mouse embryonic stem (ES) cell chromatin structure, we previously identified 62 genes required for ES cell viability. Among these 62 genes were Smc2 and -4, which are core components of the two mammalian condensin complexes. In this study, we show that for Smc2 and -4, as well as an additional 49 of the 62 genes, knockdown (KD) in somatic cells had minimal...

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Identifiers

PMID: 20176923
DOI: 10.1083/jcb.200908026
PMCID: PMC2828918

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