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Complement receptor 1 polymorphisms and risk of late-onset Alzheimer's disease.

Brain research - 12 Aug 2010

Zhang Qun, Yu Jin-Tai, Zhu Qi-Xiu, Zhang Wei, Wu Zhong-Chen, Miao Dan, Tan Lan

Abstract excerpt

The amyloid beta-protein (Abeta)-induced complement system activation plays an important role in Alzheimer's disease (AD). Complement receptor 1 (CR1) is thought to contribute to Abeta clearance. A recent large genome-wide association study (GWAS) has identified significant association of two single nucleotide polymorphisms (SNPs) (rs6656401 and rs3818361) in the CR1 gene with AD in Caucasians. Here, we performed...

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Aged, 80 and over
Alzheimer Disease
Apolipoproteins E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Case-Control Studies

Receptors, Complement

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PMID: 20558149
DOI: 10.1016/j.brainres.2010.06.018

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APOE

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