Article
Cardiac sodium channel regulator MOG1 regulates cardiac morphogenesis and rhythm.
Scientific reports - 23 Feb 2016
Zhou Juan, Wang Longfei, Zuo Mengxia, Wang Xiaojing, Ahmed Abu Shufian Ishtiaq, Chen Qiuyun, Wang Qing K
Abstract excerpt
MOG1 was initially identified as a protein that interacts with the small GTPase Ran involved in transport of macromolecules into and out of the nucleus. In addition, we have established that MOG1 interacts with the cardiac sodium channel Nav1.5 and regulates cell surface trafficking of Nav1.5. Here we used zebrafish as a model system to study the in vivo physiological role of MOG1. Knockdown of mog1 expression in...
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