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Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome

9 Jan 2024

Abstract excerpt

Notch signaling controls multiple aspects of embryonic development and adult homeostasis. Alagille syndrome is usually caused by a single mutation in the jagged canonical Notch ligand 1 (JAG1), and manifests with liver disease and cardiovascular symptoms that are a direct consequence of JAG1 haploinsufficiency. Recent insights into Jag1/Notch-controlled developmental and homeostatic processes explain how...

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PMID: 38194749
DOI: 10.1016/j.ceb.2023.102302

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