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Article

Voltage-gated sodium channels are required for heart development in zebrafish.

Circulation research - 30 Apr 2010

Chopra Sameer S, Stroud Dina Myers, Watanabe Hiroshi, Bennett Jeffrey S, Burns C Geoffrey, Wells K Sam, Yang Tao, Zhong Tao P, Roden Dan M

Abstract excerpt

RATIONALE: Voltage-gated sodium channels initiate action potentials in excitable tissues. Mice in which Scn5A (the predominant sodium channel gene in heart) has been knocked out die early in development with cardiac malformations by mechanisms which have yet to be determined. OBJECTIVE: Here we addressed this question by investigating the role of cardiac sodium channels in zebrafish heart development. METHODS AND...

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Identifiers

PMID: 20339120
DOI: 10.1161/CIRCRESAHA.109.213132
PMCID: PMC2869449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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