Article
MOG1: a new susceptibility gene for Brugada syndrome.
Circulation. Cardiovascular genetics - 1 Jun 2011
Kattygnarath Darouna, Maugenre Svetlana, Neyroud Nathalie, Balse Elise, Ichai Carole, Denjoy Isabelle, Dilanian Gilles, Martins Raphaël P, Fressart Véronique, Berthet Myriam, Schott Jean Jacques, Leenhardt Antoine, Probst Vincent, Le Marec Hervé, Hainque Bernard, Coulombe Alain, Hatem Stéphane N, Guicheney Pascale
Abstract excerpt
BACKGROUND: Brugada syndrome (BrS) is caused mainly by mutations in the SCN5A gene, which encodes the α-subunit of the cardiac sodium channel Na(v)1.5. However, ≈ 20% of probands have SCN5A mutations, suggesting the implication of other genes. MOG1 recently was described as a new partner of Na(v)1.5, playing a potential role in the regulation of its expression and trafficking. We investigated whether mutations in...
Topics
- Amino Acid Sequence
- Animals
- Brugada Syndrome
- DNA Mutational Analysis
- Electrocardiography
- Female
- Genetic Predisposition to Disease
- HEK293 Cells
- Humans