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Article

Gene therapy targeting protein trafficking regulator MOG1 in mouse models of Brugada syndrome, arrhythmias, and mild cardiomyopathy.

Science translational medicine - 8 Jun 2022

Yu Gang, Chakrabarti Susmita, Tischenko Miroslava, Chen Ai-Lan, Wang Zhijie, Cho Hyosuk, French Brent A, Naga Prasad Sathyamangla V, Chen Qiuyun, Wang Qing K

Abstract excerpt

Brugada syndrome (BrS) is a fatal arrhythmia that causes an estimated 4% of all sudden death in high-incidence areas. SCN5A encodes cardiac sodium channel NaV1.5 and causes 25 to 30% of BrS cases. Here, we report generation of a knock-in (KI) mouse model of BrS (Scn5aG1746R/+). Heterozygous KI mice recapitulated some of the clinical features of BrS, including an ST segment abnormality (a prominent J wave) on...

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Identifiers

PMID: 35675436
DOI: 10.1126/scitranslmed.abf3136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gene therapy targeting protein trafficking regulator MOG1 in mouse models of Brugada syndrome, arrhythmias, and mild cardiomyopathy.PMID 35675436Read ↗

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