Article
Gene therapy targeting protein trafficking regulator MOG1 in mouse models of Brugada syndrome, arrhythmias, and mild cardiomyopathy.
Science translational medicine - 8 Jun 2022
Yu Gang, Chakrabarti Susmita, Tischenko Miroslava, Chen Ai-Lan, Wang Zhijie, Cho Hyosuk, French Brent A, Naga Prasad Sathyamangla V, Chen Qiuyun, Wang Qing K
Abstract excerpt
Brugada syndrome (BrS) is a fatal arrhythmia that causes an estimated 4% of all sudden death in high-incidence areas. SCN5A encodes cardiac sodium channel NaV1.5 and causes 25 to 30% of BrS cases. Here, we report generation of a knock-in (KI) mouse model of BrS (Scn5aG1746R/+). Heterozygous KI mi...
Topics
- Animals
- Arrhythmias, Cardiac
- Brugada Syndrome
- Cardiomyopathies
- Death, Sudden
- Disease Models, Animal
- Genetic Therapy
- Mice
- Mutation
- NAV1.5 Voltage-Gated Sodium Channel
- Protein Transport