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Article

Generation of a homozygous RANGRF knockout hiPSC line by CRISPR/Cas9 system.

Stem cell research - 1 Sept 2023

Jiang Meiling, Tang Chengcheng, Luo Xian, Zhou Xiaoqing, Chen Min, Chi Yue, Lai Liangxue, Zou Qingjian

Abstract excerpt

The RAN Guanine Nucleotide Release Factor (RANGRF) gene encodes the protein MOG1, which binds to Nav1.5 and facilitates its transport to the cell membrane. Nav1.5 mutations have been linked to various cardiac arrhythmias and cardiomyopathy. To investigate the role of RANGRF in this process, we utilized the CRISPR/Cas9 gene editing system to generate a homozygous RANGRF knockout hiPSC line. The availability of the...

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PMID: 37327621
DOI: 10.1016/j.scr.2023.103136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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