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Cardiac Na+-Ca2+ exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish.

Science China. Life sciences - 1 Feb 2021

Chu Liming, Yin Huimin, Gao Lei, Gao Li, Xia Yu, Zhang Chiyuan, Chen Yi, Liu Tingxi, Huang Jijun, Boheler Kenneth R, Zhou Yong, Yang Huang-Tian

Abstract excerpt

Ca2+ signaling is critical for heart development; however, the precise roles and regulatory pathways of Ca2+ transport proteins in cardiogenesis remain largely unknown. Sodium-calcium exchanger 1 (Ncx1) is responsible for Ca2+ efflux in cardiomyocytes. It is involved in cardiogenesis, while the mechanism is unclear. Here, using the forward genetic screening in zebrafish, we identified a novel mutation at a...

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PMID: 32648190
DOI: 10.1007/s11427-019-1706-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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