Article
Mechanistic insights into the interaction of cardiac sodium channel Nav1.5 with MOG1 and a new molecular mechanism for Brugada syndrome.
Heart rhythm - 1 Mar 2022
Xiong Hongbo, Bai Xuemei, Quan Zhuang, Yu Dong, Zhang Hongfu, Zhang Chi, Liang Lina, Yao Yufeng, Yang Qin, Wang Zhijie, Wang Longfei, Huang Yuan, Li Hui, Ren Xiang, Tu Xin, Ke Tie, Xu Chengqi, Wang Qing K
Abstract excerpt
BACKGROUND: Mutations in cardiac sodium channel Nav1.5 cause Brugada syndrome (BrS). MOG1 is a chaperone that binds to Nav1.5, facilitates Nav1.5 trafficking to the cell surface, and enhances the amplitude of sodium current INa. OBJECTIVE: The purpose of this study was to identify structural elem...
Topics
- Brugada Syndrome
- Heart
- Humans
- Long QT Syndrome
- Mutation
- NAV1.5 Voltage-Gated Sodium Channel