Article

MOG1 <sup>L18F</sup> -mediated increase in late sodium current produces Long QT Syndrome

2025-12-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Na V 1.5 channels, encoded by SCN5A , are essential for the genesis and shaping of the cardiac action potential (AP). Gain-of-function (GoF) variants in SCN5A are associated with long QT syndrome (LQTS), whereas loss-of-function (LoF) mutations are linked with Brugada syndrome. MOG1 is an integral part of the Na V 1.5 channelosome, increasing both current and membrane e...

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Literature Corpus work: 6ebbcc5c-57fc-5420-9d5e-984f4baa32f0
DOI: 10.64898/2025.12.12.25340695

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