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Article

Neuregulin-1 is essential for nerve plexus formation during cardiac maturation.

Journal of cellular and molecular medicine - 1 Mar 2018

Brown Daniel, Samsa Leigh Ann, Ito Cade, Ma Hong, Batres Karla, Arnaout Rima, Qian Li, Liu Jiandong

Abstract excerpt

The Neuregulin-1 (Nrg1)/ErbB pathway plays multiple, critical roles in early cardiac and nervous system development and has been implicated in both heart and nerve repair processes. However, the early embryonic lethality of mouse Nrg1 mutants precludes an analysis of Nrg1's function in later cardiac development and homeostasis. In this study, we generated a novel nrg1 null allele targeting all known isoforms of...

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Identifiers

PMID: 29265764
DOI: 10.1111/jcmm.13408
PMCID: PMC5824398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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