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Article

Brain serotonin 4 receptor binding is associated with the cortisol awakening response.

Psychoneuroendocrinology - 1 May 2016

Jakobsen Gustav R, Fisher Patrick M, Dyssegaard Agnete, McMahon Brenda, Holst Klaus K, Lehel Szabolcs, Svarer Claus, Jensen Peter S, Knudsen Gitte M, Frokjaer Vibe G

Abstract excerpt

Serotonin signalling is considered critical for an appropriate and dynamic adaptation to stress. Previously, we have shown that prefrontal serotonin transporter (SERT) binding is positively associated with the cortisol awakening response (CAR) (Frokjaer et al., 2013), which is an index of hypothalamic-pituitary-adrenal (HPA)-axis output dynamics. Here, we investigated in healthy individuals if cerebral serotonin...

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PMID: 26894483
DOI: 10.1016/j.psyneuen.2016.01.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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