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Article

Serotonin transporter gene-linked polymorphic region (5-HTTLPR) and diurnal cortisol: A sex by genotype interaction.

Biological psychology - 1 Oct 2010

Wankerl Matthis, Zyriax Birgit-Christiane, Bondy Brigitta, Hinkelmann Kim, Windler Eberhard, Otte Christian

Abstract excerpt

In interaction with stressful life events, the serotonin transporter gene-linked polymorphic region (5-HTTLPR) is associated with depression. In response to stress, the hypothalamic-pituitary-adrenal (HPA) axis is activated. HPA activity is often increased in depression. Thus, one potential mechanism by which 5-HTTLPR might increase risk for depression is by its impact on HPA activity. We examined the effects of...

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PMID: 20637828
DOI: 10.1016/j.biopsycho.2010.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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