Article
Oestradiol alters central 5-HT1A receptor binding potential differences related to psychosocial stress but not differences related to 5-HTTLPR genotype in female rhesus monkeys.
Journal of neuroendocrinology - 1 Feb 2014
Michopoulos V, Perez Diaz M, Embree M, Reding K, Votaw J R, Mun J, Voll R J, Goodman M M, Wilson M, Sanchez M, Toufexis D
Abstract excerpt
Social subordination in female macaques represents a well-described model of chronic psychosocial stress. Additionally, a length polymorphism (5-HTTLPR) in the regulatory region of the serotonin (5-HT) transporter (5-HTT) gene (SLC6A4) is present in rhesus macaques, which has been linked to adverse outcomes similar to that described in humans with an analogous 5-HTTLPR polymorphism. The present study determined...
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