Article
Common functional mineralocorticoid receptor polymorphisms modulate the cortisol awakening response: Interaction with SSRIs.
Psychoneuroendocrinology - 1 May 2011
Klok Melanie D, Vreeburg Sophie A, Penninx Brenda W J H, Zitman Frans G, de Kloet E Ron, DeRijk Roel H
Abstract excerpt
BACKGROUND: Cortisol controls the activity of the hypothalamic-pituitary-adrenal (HPA) axis during stress and during the circadian cycle through central mineralocorticoid (MR) and glucocorticoid receptors (GR). Changes in MR and GR functioning, therefore, may affect HPA axis activity. In this study we examined the effect of common functional MR gene variants on the cortisol awakening response (CAR), which is...
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