Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Variations in central serotonergic activity - relevance of the 5-HTTLPR, life events and their interaction.

Behavioural brain research - 15 Jan 2015

Wielpuetz Catrin, Kuepper Yvonne, Grant Phillip, Munk Aisha Judith Leila, Hennig Juergen

Abstract excerpt

The 5-HTTLPR and its interaction with adverse life events has been studied widely; especially with regard to depression. Few studies are available relating the respective association with acute serotonergic functionality. We examined the effects of the 5-HTTLPR, life events and their interaction on serotonergic responsivity using S-citalopram (10mg) in a placebo-controlled double-blind neuroendocrine challenge...

Topics

Adolescent
Adult
Citalopram
Depression
Depressive Disorder
Double-Blind Method
Female
Genetic Predisposition to Disease
Genotype
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Serotonin

Serotonin Plasma Membrane Transport Proteins

Selective Serotonin Reuptake Inhibitors

Young Adult

Source

Identifiers

PMID: 24374553
DOI: 10.1016/j.bbr.2013.12.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variations in central serotonergic activity - relevance of the 5-HTTLPR, life events and their interaction.PMID 24374553Read ↗

Variability in the Effect of 5-HTTLPR on Depression in a Large European Population: The Role of Age, Symptom Profile, Type and Intensity of Life StressorsSemantic proximity Read ↗

Effects of acute psychosocial stress exposure on endocrine and affective reactivity in college students differing in the 5-HTTLPR genotype and trait neuroticism.Semantic proximity Read ↗

Serotonin transporter genotype, salivary cortisol, neuroticism and life events: impact on subsequent psychopathology in healthy twins at high and low risk for affective disorder.Semantic proximity Read ↗

Gene-environment interactions predict cortisol responses after acute stress: implications for the etiology of depression.Semantic proximity Read ↗

Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol.Semantic proximity Read ↗

Interaction between the 5-HTTLPR genotype, impact of stressful life events, and trait neuroticism on depressive symptoms in healthy volunteers.Semantic proximity Read ↗

COMT but Not 5HTTLPR Gene Is Associated with Depression in First-Episode Psychosis: The Role of Stressful Life Events.Semantic proximity Read ↗

5-HTTLPR S-allele: a genetic plasticity factor regarding the effects of life events on personality?Semantic proximity Read ↗

5-HTTLPR moderates effects of current life events on neuroticism: differential susceptibility to environmental influences.Semantic proximity Read ↗

Associations of the serotonin transporter gene polymorphism, 5-HTTLPR, and adverse life events with late life depression in the elderly Lithuanian population.Semantic proximity Read ↗

Affective and neuroendocrine stress reactivity to an academic examination: influence of the 5-HTTLPR genotype and trait neuroticism.Semantic proximity Read ↗

Serotonin as a Biocultural Molecule: Circular Causality, Stress, and PsychopathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.