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Article

Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype is associated with cortisol responsivity to naloxone challenge.

Psychopharmacology - 1 Nov 2012

Stephens Mary Ann C, McCaul Mary E, Weerts Elise M, Wand Gary

Abstract excerpt

RATIONALE: The serotonergic and opioidergic neurotransmitter systems are critical regulators of the hypothalamic-pituitary-adrenal (HPA) axis through their respective excitatory and inhibitory inputs. Serotonin transporter (5-HTT) genotype has been studied as a marker of HPA axis dysregulation and for predicting risk of psychopathology, with mixed findings. OBJECTIVES: We stimulated the HPA axis with naloxone, an...

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Source

Identifiers

PMID: 22623017
DOI: 10.1007/s00213-012-2742-9

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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