Article
BDNF rs6265 methylation and genotype interact on risk for schizophrenia.
Epigenetics - 1 Jan 2016
Ursini Gianluca, Cavalleri Tommaso, Fazio Leonardo, Angrisano Tiziana, Iacovelli Luisa, Porcelli Annamaria, Maddalena Giancarlo, Punzi Giovanna, Mancini Marina, Gelao Barbara, Romano Raffaella, Masellis Rita, Calabrese Francesca, Rampino Antonio, Taurisano Paolo, Di Giorgio Annabella, Keller Simona, Tarantini Letizia, Sinibaldi Lorenzo, Quarto Tiziana, Popolizio Teresa, Caforio Grazia, Blasi Giuseppe, Riva Marco A, De Blasi Antonio, Chiariotti Lorenzo, Bollati Valentina, Bertolino Alessandro
Abstract excerpt
Epigenetic mechanisms can mediate gene-environment interactions relevant for complex disorders. The BDNF gene is crucial for development and brain plasticity, is sensitive to environmental stressors, such as hypoxia, and harbors the functional SNP rs6265 (Val(66)Met), which creates or abolishes a CpG dinucleotide for DNA methylation. We found that methylation at the BDNF rs6265 Val allele in peripheral blood of...
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