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Brain-derived neurotrophic factor (BDNF) epigenomic modifications and brain-related phenotypes in humans: A systematic review.

Neuroscience and biobehavioral reviews - 1 Apr 2023

Treble-Barna Amery, Heinsberg Lacey W, Stec Zachary, Breazeale Stephen, Davis Tara S, Kesbhat Aboli A, Chattopadhyay Ansuman, VonVille Helena M, Ketchum Andrea M, Yeates Keith Owen, Kochanek Patrick M, Weeks Daniel E, Conley Yvette P

Abstract excerpt

Epigenomic modifications of the brain-derived neurotrophic factor (BDNF) gene have been postulated to underlie the pathogenesis of neurodevelopmental, psychiatric, and neurological conditions. This systematic review summarizes current evidence investigating the association of BDNF epigenomic modifications (DNA methylation, non-coding RNA, histone modifications) with brain-related phenotypes in humans. A novel...

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PMID: 36764636
DOI: 10.1016/j.neubiorev.2023.105078
PMCID: PMC10164361

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