Article
Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Jul 2003
Hariri Ahmad R, Goldberg Terry E, Mattay Venkata S, Kolachana Bhaskar S, Callicott Joseph H, Egan Michael F, Weinberger Daniel R
Abstract excerpt
BDNF plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. A frequent single nucleotide polymorphism in the targeting region of the human BDNF gene (val66met) has been associated with abnormal intracellular trafficking and regulated secretion of BDNF in cultured hippocampal neurons transfected with the met allele. In addition, the met allele has been...
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