Methylation of Brain Derived Neurotrophic Factor (BDNF) Val66Met CpG site is associated with early onset bipolar disorder.

doi:10.1016/j.jad.2020.02.002

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Article

Methylation of Brain Derived Neurotrophic Factor (BDNF) Val66Met CpG site is associated with early onset bipolar disorder.

Journal of affective disorders - 15 Apr 2020

Nassan Malik, Veldic Marin, Winham Stacey, Frye Mark A, Larrabee Beth, Colby Colin, Biernacka Joanna, Bellia Fabio, Pucci Mariangela, Terenius Lars, Vukojevic Vladana, D'Addario Claudio

Abstract excerpt

BACKGROUND: The brain-derived neurotrophic factor (BDNF) rs6265 (Val66Met) Met allele is associated with early onset (≤ 19 years old) bipolar disorder (BD). Val66Met (G196A) creates a CpG site when the Val/G allele is present. We sought to study the methylation of the BDNF promoter and its interaction with Val66Met genotype in BD. METHODS: Sex/age-matched previously genotyped DNA samples from BD-Type 1 cases...

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PMID: 32063579
DOI: 10.1016/j.jad.2020.02.002

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